Self-folding and self-assembly represent two distinct strategies for the automatic formation of 3D structures, each governed by different physical principles. While self-assembly relies on the spontaneous organization of multiple discrete parts through local interactions (e.g. liquid bilayer, virus capsule), self-folding involves the transformation of a single, continuous 2D sheet with hinges/folds into a 3D shape (e.g. protein folding, dna origami). This project aims to compare these two paradigms and understand how the initial connectivity of a system affects the fabrication rate, reliability and efficiency of the fabrication process. By integrating computational modeling with experimental observations, we will try to compare the benefits and constraints of each fabrication process.